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Department of Pharmacology

Decoding the science of drug action to drive clinical innovation. We integrate foundational biology with therapeutic application through industry-collaborative research and ethical animal studies.

The Department of Pharmacology at AVMCH is a dynamic discipline that bridges anatomy, physiology, and biochemistry with clinical therapeutics. We focus on rational prescribing, drug safety, and innovation in therapeutics. Our department is a designated Pharmacovigilance center and maintains a CCSEA-registered central animal house supporting ethical research and Phase IV clinical trials.

CCSEA Registered Animal House

Designated Pharmacovigilance Centre

Phase IV Clinical Trial Centre

Department

From molecular mechanisms to clinical cures.

We focus on the scientific study of drug actions, emphasizing rational prescribing and the ethical exploration of both natural and synthetic chemical agents.

Pharmacology is the study of how chemical agents affect biological systems, from subcellular mechanisms to systemic responses. At AVMC, we go beyond memorizing drug names; we teach the fundamental principles that enable students to apply knowledge from the molecular level to real-life clinical scenarios. Our department actively contributes to Phase IV clinical trials and post-marketing surveillance, ensuring the highest standards of drug safety.

We offer comprehensive training for 150 MBBS, 2 MD Pharmacology, and nearly 200 paramedical students annually across nursing, physiotherapy, and medical biotechnology. Our curriculum emphasizes rational therapeutics, experimental pharmacology, and drug safety. Supported by a CCSEA-registered animal house and a lush herbal garden with 50+ species, we provide an environment where ethical research and academic innovation thrive.

The department maintains a strong leadership role in institutional governance, research oversight, and quality assurance initiatives.

Our designated Pharmacovigilance centre is critical for detecting and preventing ADRs, supporting evidence-based prescribing across all clinical departments.

Research Focus

Thrust · Herbal Validation, Pharmacovigilance, Pre-clinical Trials

Outreach

Outreach · Patient Safety Awareness & Regional ADR Monitoring

Building competency in rational therapeutics.

Academic Programmes

Programme 01148 / 150 ADMITTED

MBBS

Undergraduate Core

Seats permitted150

Focusing on core concepts of pharmacology, rational prescribing, and clinical application as per the competency-based curriculum.

Programme 022 / 2 ADMITTED

MD Pharmacology

Postgraduate Specialty

Seats permitted2

Advanced training in experimental pharmacology, clinical trials, and drug safety surveillance.

Programme 03200+ ENROLLED

Paramedical

Nursing · Physiotherapy · Medical Biotechnology

Learners / year200

Foundational pharmacology training for the paramedical streams — nursing, physiotherapy, and medical biotechnology.

Head of Department

Expert in Clinical Pharmacology.

Dr. K. Madhanagopal, Professor & HOD, leads the department with a focus on therapeutics and safety.

Dr. K. Madhanagopal

Dr. K. Madhanagopal

Professor & Head · MBBS, MD

Dr. Madhanagopal is a leading voice in clinical pharmacology and drug safety. He oversees the institutional pharmacovigilance pathways and leads research into herbal validation and MASLD. Under his leadership, the department has become a key contributor to Phase IV clinical trials and ethical animal research.

Research · Thrust Areas

Innovation in Safety & Therapeutics.

Herbal Validation

Two ongoing herbal validation studies — identification, standardization, and validation of medicinal plants for safety and efficacy using modern scientific tools.

Pharmacovigilance

Systematic monitoring of adverse drug reactions (ADRs) to ensure patient safety and evidence-based medicine.

Pre-Clinical Studies

Evaluation of drug safety through in-vitro and in-vivo studies, including toxicological profiling and biomarker discovery.

Research & Innovation

A robust portfolio of clinical inquiry.

The department is a hub for diverse pharmacological research, ranging from herbal muscle relaxants to AI-guided molecular docking for TB.

Research Snapshot

21 projects since 2023 5 shown below

self-funded and intramural

#ProjectPIFundingFocusStatus
01Evaluation of Skeletal Muscle Relaxant Effects of Apigenin Alone and in Combination with Baclofen in Swiss Albino MiceMs. Lakshna/ Dr. VijayasanthiSelfUndergraduateOngoing
02Topical antipruritic effects of Coccinia grandis in Histamine induced scratching in Guinea pigMr.Dhayanithi/ Dr. VijayasanthiSelfUndergraduateOngoing
03Evaluation of Skeletal Muscle Relaxant Property of Leaves Powder of Melissa officinalis in Swiss Albino MiceMs. Pratishtha Pandey/ Dr.Franc Deepika Venugopan.SelfUndergraduateOngoing
04Effect of Pantoprazole and Vonoprazan on serum calcium and renal parameters in adult albino Wistar ratsMs. Sowmiya Devi/ Dr. Meganathan.SelfUndergraduatecompleted
05Effect of Imeglimin in diabetic nephropathy induced by STZ in adult albino Wistar ratsMs. Harini/ Dr.DeepakameswariSelfUndergraduateCompleted · Not Published
06Assessment of Medication adherence among patients with Hypertension & Diabetes mellitus in a tertiary care hospital: a cross sectional studyShalini/ Dr.DeepakameswariSelfUndergraduateOngoing
07Drug utilization pattern among pregnant women attending clinics of a tertiary care hospital: A cross sectional studySnehalatha K. V/ Dr.DeepakameswariSelfUndergraduateOngoing
08Preclinical screening of aqueous extract of Citrullus lanatus rind in high-fat diet induced hyperlipidemia in adult albino Wistar ratsDr. Kalavakunta Sravani/ Dr. K. MadhanagopalSelfPostgraduateOngoing
09Comparative study on the effectiveness of Imeglimin, Saroglitazar and Empagliflozin in high-fat diet induced MASLD in adult albino Wistar ratsDr. J. Banupriya/ Dr. MeganathanSelfPostgraduateOngoing
10Multi-omics Identification of Ferroptosis- Related Diagnostics biomarker in Atrial FibrillationNandini Yadav/ Dr. Sivaraj RengarajSelfUndergraduateOngoing
11Integrated Machine Learning Analysis identifies molecular bridges between Osteoarthritis & Metabolic syndromePalash Sharma/ Dr. Sivaraj RengarajSelfUndergraduateOngoing
12Identifying diagnostic mi RNA biomarkers in triple negative Breast cancer using bioinformatics approachesAadhira Muthukumaran/ Dr. Sivaraj RengarajSelfUndergraduateOngoing
13Chronic opioid (morphine and methadone) exposure and alterations in emotional regulations & social behaviors: a systematic review & meta analysisVed Sanjay Malviya/ Dr. Sivaraj RengarajSelfUndergraduateOngoing
14AI- guided modeling & molecular docking of micronutrient- responsive targets in TuberculosisDr. Dhivya S. R/ Dr. Sivaraj RengarajSelfPostgraduateOngoing
15Exploring micronutrient- responsive targets in tuberculosis: AI integrated modeling &Molecular dockingDr. Dhivya Rajasekaran/ Dr. Sivaraj RengarajSelfPostgraduateCompleted · Not published
16AI driven pharmacogenomic modeling of gene- micronutrient interactions in Pulmonary TB patientsDr. Dhivya Rajasekaran/Dr. Sivaraj RengarajSelfPostgraduateCompleted · Not published
17Comparative study on the potentiation of antidepressants activity by caffeine & nicotine in combination with standard antidepressants in mice modelSahil Nazir Khan/ Dr. NarayanasamyintramuralUndergraduateOngoing
18Analysis of drug expiry and wastage trends in the hospital pharmacy. A 3yr retrospective reviewDr. Ramprabu/ Dr. Sivaraj RengarajSelfPostgraduateOngoing
19Retrospective study of prescribing trends of proton pump inhibitors in the outpatient pharmacyDr. Ramprabu/ Dr. Sivaraj RengarajSelfPostgraduateOngoing
20A cross sectional KAP study of antimicrobial stewardship among 2nd year to final year mbbs students and intern in teaching hospital in pudhucerryDr. Ramprabu / Dr. Sivaraj RengarajSelfPostgraduateOngoing
21Pattern of antibiotic prescription for lower respiratory tract infection in a tertiary care hospital in comparison with standard treatment ICMR GuidelinesDr. Ramprabu / Dr. Sivaraj RengarajSelfPostgraduateOngoing
Publications

Leading research in global journals.

Sub-acute toxicological assessment of ethanolic extract of Achyranthes aspera L. in Wistar rats

Journal of Pharmaceutical Negative Results · 2022 · 590–8

Madhanagopal K, Deepa Kameswari KP, Meganathan M, Balamurugan K

Zingiberene attenuates high fat diet-induced non-alcoholic fatty liver disease through suppression of lipogenesis and oxidative stress in rats

Comparative Clinical Pathology · 2022 · 31(2):201–9

Sivaraj R, Jaikumar S, Sengottuvelu S

Morphometric assessment of the external anatomy of fourth ventricle and dorsal brainstem in South Indian population

International Journal of Health Sciences · 2022 · 6(S6):9609–9614

Umarani S, Arjun R, Kumar S, Sivaraj R

Study of variations of anterior cerebral artery in human cadavers of South Indian population

NeuroQuantology · 2022 · 20(8):9054–55

Umarani S, Arjun R, Shishir Kumar, Sivaraj R, Sanjay Kumar Revankar, Reddy Spoorti Channa, Aparna, Chetana YK

Zingiberene protects from isoproterenol-induced cardiotoxicity via attenuation of hyperlipidemia and oxidative stress in rats

Revista Brasileira de Farmacognosia · 2022 · 32(1):74–80

Asokan BR, Jaikumar S, Sengottuvelu S

Responsible research in planning for animal experiments - a mini review

International Journal of Pharmaceutical Investigation · 2022 · 12(4):400–402

Leena Rajathy Port Louis, Prithiviraj Nagarajan, Asokan Balakrishnan Ramajayam

Biochemical estimation of the effects of aged garlic extract against streptozocin-nicotinamide on liver hepatocyte cells and kidney cells in rats

Journal of Clinical and Diagnostic Research · 2023 · 14(7):1125–1133

Sivaraj R, Shajahan A, Arbind Kumar Choudhary, Aishwarya Umashankar, Sanathanan, Abirami R

The study on demographic factors and VKORC1 -1630 G>A gene polymorphism using PCR-RFLP in the South Indian population

Biological Forum - An International Journal · 2023 · 15(3)

Bala Tripura Sundari Ankani R

Pharmacogenomics of warfarin: recent advances

European Chemical Bulletin · 2023 · 12(3):2539–2551

Balatripurasundari, Sivaraj R, Harivadan Lukka Sunilkumar Pandey

Effect of Azadirachta indica against sodium benzoate induced hepatorenal toxicity in Wistar rats - an experimental interventional study

Journal of Clinical and Diagnostic Research · 2023 · 17(4):FC12–FC16

Kameswari D, Ezhil V, Perumal V, Manju M, Meganathan M, Madhanagopal K

A study from South India on the genetic and non-genetic variables that influence an individual's warfarin dose requirement

European Chemical Bulletin · 2023 · 12(6):2462–2473

Bala Tripura Sundari, Sivaraj R, Sudar Codi R, Somasundaram G, Indla Ravi

Blood collection guidelines and collection techniques in small laboratory animals - a systematic review

International Journal of Life Science and Pharma Research · 2023 · 13(2)

Leena Rajathy Port Louis, Prithiviraj Nagarajan, Asokan Balakrishnan Ramajayam

Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis

Open Access Archive · 2023 · 7833

Roy A, Neelakantappa VM, Ganesan J, Asokan BR

Green synthesized silver nanoparticles using Anoectochilus elatus leaf extract: characterization and evaluation of antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities

Journal of Composites Science · 2023

Venkataesan Kumari, Bhuvaneshwari et al.

Analysis of the prevalence and pattern of polypharmacy among elderly patients in the General Medicine and Orthopaedic departments of a tertiary care hospital in Puducherry

Job stress, anxiety, depression and coping among professionals and non-professionals during the COVID second wave in a tertiary care hospital

Global Journal of Health Sciences and Research · 2023 · 1:1–6

Kulothungan V, Sivakumar P, Selvaraj A, Dhamodharan A, Vijayan SM

Molecular docking analysis of flavonoids with AChE and BACE-1

Bioinformation · 2024 · 20(2):103–109

Viswanathan S, Arumugam T, Subramanian K, Sivaraj R, Ramesh V, Vasanthi AHR

Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation

Systems Biology in Reproductive Medicine · 2024 · 70(1):20–37

Uddandrao VVS, Eraniappan S, Balakrishnan Ramajayam A, Singaravel S, Roy A, Parim BN, Ponnusamy C, Ganapathy S, Ponnusamy P, Sasikumar V

In vitro mechanistic study on antiradical and hepatoprotective activity of Ruta graveolens leaf extract

African Journal of Biological Sciences · 2024 · 6:1126–1136

Joshi D, Asokan B, Singh S, Krishna V, Kadam S, Rihana S, Begum T, Abhang V, Kumar D

Prediction of warfarin dosage based on genotype VKORC1 -1639 G>A (rs9923231) in South Indian populations

International Journal of Pharmaceutical Quality Assurance · 2024 · 15(2):611–615

Bala A, Sivaraj R

Warfarin dose maintenance associated with CYP2C9*2 (rs1799853) and CYP2C9*3 (rs1057910) gene polymorphism in North Coastal Andhra Pradesh

The Open Biochemistry Journal · 2024 · 1:1–7

Rengaraj, Sivaraj R

From network pharmacology to molecular docking analysis of sterubin targets for Alzheimer's disease

Bioinformation · 2024 · 20(4):327–336

Viswanathan S, Arumugam T, Sivaraj R, Subhashri Rajendran S, Ramesh V, Subramanian K, Vasanthi AHR

An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer's disease

Journal of Receptors and Signal Transduction Research · 2024

Viswanathan S, Sivaraj R, Vasanthi AHR, Subramanian K, Ramesh V

Development and evaluation of granisetron transdermal patches for supportive therapy of chemotherapy induced nausea and vomiting

Bulletin of Pure and Applied Sciences - Zoology · 2024

Ravikumar BS, Asokan BR, Viswanadh K, Hasmi W, Khatoon Y et al.

Innovative extraction methods and solvent optimization for Paederia foetida: in vitro analysis of antioxidant and neuroprotective properties

Bulletin of Pure and Applied Sciences - Zoology · 2024

Tripathi G, Komal Kriti, Kavitha S, Asokan BR, Pankaj MP et al.

The DPP-IV inhibition, glucose uptake and nephroprotective potential of an herbal remedy of Balbisia pedunculata and Allium sativum

African Journal of Biological Sciences · 2024 · 6(6):5430–5441

Asokan BR, Parida NR, Singh VP, Divya M, Dwivedi SK, Tiwari N, Singh AP, Tripathi G

Beneficial effect of genistein in paclitaxel-induced neuropathic pain in albino Wistar rats

International Journal of Pharmaceutical and Clinical Research · 2024 · 16(9):818–22

Deepa Kameswari, Nitya S, Meenakshi R

A comparative evaluation and pharmacological assessment of Abelmoschus manihot leaves extract: in vitro antidiabetic and neuroprotective activities and their effects on glucose uptake and DPP-4 inhibition

The Bioscan · 2024 · 19(Suppl 2):428–435

Ramenani Hari Babu, Maneesha Bhardwaj, Asokan BR, Deblina Sardar, Teja Sruthi PVR, Aniruddha Mukherjee, Vema Kiran

Pharmacological evaluation of anti-inflammatory and antioxidant potential of Cuscuta reflexa methanol extract: role in inhibition of cyclooxygenase and lipoxygenase

South Eastern European Journal of Public Health · 2024 · 1555–1564

Sharma H, Asokan B, Imam S, Begum T, Jaiswal P, Babu RH, Bhadkar TK

Formulation and evaluation of diclofenac sodium injection

Cuestiones de Fisioterapia · 2024 · 53(3):5002–5009

Madhanagopal K, Balamurugan K

Study of knowledge, attitude and practices of self-medication among medical and nursing students in a medical college, Puducherry

International Journal of Pharma and Bio Sciences · 2025 · 16(1):53–62

Kar S, Narayanasamy S, Singh V, Sharma A, Vijayasanthi T, Asokan BR et al.

Impact of CYP2C9 and VKORC1 genetic variants on warfarin therapy optimization in South Indian population with venous thromboembolism

Journal of Population Therapeutics and Clinical Pharmacology · 2025 · 32(9)

Sundari ABT, Syamala D, Sivaraj R, Somasundaram G, Sudar Codi R

Formulation and evaluation of moxifloxacin hydrochloride ophthalmic solution USP

Journal of Dalian University of Technology · 2025 · 32(3):61

Balamurugan K, Deepakameswari P

Evaluation of the wound healing effect of topical and oral Trigonella foenum-graecum seed oil on burn wound in an animal model

National Board of Examinations Journal of Medical Sciences · 2026 · 4(2):125–37

Anandh VT, Narayanasamy S, Rajathy L

Genistein influences behavioral and neuroendocrine responses in an antibiotic-induced physiological stress model

International Journal of Drug Delivery Technology · 2026 · 16(52s):761–768

Velmurugan S, Perumal DK, Pugazhendhi S, Jayakrishnan M, Mani M, Kannaiyan M, Louis LR

Philosophy

Pharmacology · AVMCH

Beyond memorization: Understanding principles from molecular mechanisms to patient-care context.

Department of Pharmacology, AVMCH & Hospital

Awards & Recognitions

Excellence in Pharmacology.

Guest Speaker "Effective study strategies for smarter learning "

Dr. T. Vijayasanthi

SMVMCH · 01. 12.2025

Organized V Connect ALUMNI MEET -2025 as President

Dr.S. Narayanasamy

Alumni Association, AVMCH · 05.12.2025

Resource Person “Medical Education Technology for PG Students”

Dr.P.Deepakameswari

MEU, AVMCH · 08.2.2025

Panelist "Strategic Approaches for Selecting OAD in T2DM" online Programme named DIA Logue

Dr.M.Meganathan

Microlabs · 19.12.2025

Speaker -Patient Awareness Video on Lipitension management

Dr. K. Madhanagopal

Microlabs · 5.12.2025

R a p p o r t e u r - SOUTH ZONAL IAVP CONFERENCE-2025

Dr. Leena Rajathy Portlouis

Rajiv Gandhi institute of veterinary education and Research, Puducherry, India · 2025

Resource Person - Gurudakshatha

Dr. P. Deepakameswari

MEU, AVMCH · 2025

Certificate of Excellence in Reviewing

Dr.P. Deepakameswari

Journal of Pharmaceutical Research International · 2025

Speaker -Role of Bisoprolol across CV Continuum - New dimensions 2025

Dr.K.Madhanagopal

MERCKS · 2025

PRIDE OF INTERNATIONAL AWARD FOR PHARMA COLLEGE -Certificate of Excellence

Dr.R.Sivaraj

GENESIS ULTIMA - DUBAI LAE · 2025

International Excellence Research in Clinical Pharma College-Certificate of Excellence

Dr.R.Sivaraj

MAHEZ foundation · 2025

Resource Person - Research Methodology Workshop on Protocol Writing

Dr.Leena Rajathy

AVMCH · 2025

Events Organised

Active Knowledge Exchange.

08

Apr 2026

Lab animal handling techniques

Workshop · presentation/

Department of pharmacology & Central animal house.

28

Jan 2026

Pharmacovigilance Week awareness program

Awareness Programme cum Short film & Poster competition · 150 UG students have attended and actively participated in the competition.

Dr. Madhanagopal, Dr. Deepakameswari

10

Sep 2024

Pharmacovigilance Week awareness program

Awareness Programme cum Short film & Poster competition · 150 UG students have attended and actively participated

Dr. Meganathan

31

Aug 2024

Pharmacovigilance & Materiovigilance

Guest lecture

Dr. Meganathan

19

Jun 2024

Orientation Program on Animal Handling Techniques

Orientation programme · 150 UG students have attended and trained for animal handling and various equipments

Dr.M.Meganathan ,Dr.R.Sivaraj,Dr.B.R.Asokan,Dr.K.Madhanagopal,Dr.Deepakameswari,Dr.S.Narayanasamy,Dr.Franc Deepika Venigopan,Dr.Leena Rajathy

19

Feb 2024

Field Visit- IGMC & Goodman Pharma Company

Electives · 150 UG students have been taught about ADR monitoring centre & about pharmacovigilance

Dr Meganathan HOD, Dr Madhanagopal Dr Deepa kameswari

Infrastructure

Specialized Research Facilities.

Central Animal House

CCSEA Registered · 3,643 sq ft

The department's principal research facility: quarantine, experimental and necropsy rooms under strict environmental control, a Zebrafish unit, and behavioural testing equipment, with every study cleared by the Institutional Animal Ethics Committee.

Herbal Garden

50+ Medicinal Varieties

Pharma Museum

30+ Crude Drug Specimens

ADR Centre

Pharmacovigilance Monitoring

Central Animal House

Ethical & Scientific Excellence.

Animal Facility

3643 Sq. Ft.

Fully equipped with quarantine, experimental, and necropsy rooms, maintained under strict environmental controls.

IAEC Board

Governed

All research is approved by the Institutional Animal Ethics Committee, ensuring humane and prudent use of animals.

Zebrafish Lab

In-vivo

Specialized housing for Zebrafish research, supporting embryos and adult studies.

Modern Instruments

Equipped

Equipped with Analgesiometers, Forced swim test apparatus, and Tail suspension apparatus.

Get in Touch

Pharmacology & Safety Hub.

For industry collaborations, research inquiries, or admissions, contact the HOD office.

HOD:Dr. K. Madhanagopal

Email:pharmacology@avmc.edu.in

IAEC:iaec@avmc.edu.in

Location:2nd Floor, College Block, AVMCH